Migrene
30/07/08 16:22
God gjennomgang av
migrene,
skrevet av Dr. Richard Craig,
Neurolog ved University of Chicago Medical Ctr.,
Chicago.
http://knol.google.com/k/richard-kraig/migraine-mechanisms-and-management/DmMyZecK/h0wPsA#
Artikkelen tar for seg hva migrene er, hvorfor og behandlingsmetoder. Noe som ofte er droppet i behandlingen er fysisk aktivitet, og viktigheten av dette. Utdrag fra artikkelen omhandlende fysisk aktivitet og migrene, og viktigheten av å ikke blindt godta genetikk som forklaring alene.
"Next is exercise! This is often neglected by patients but often included by migraine specialists as an important adjunct to improving headache care. Let’s see why. Migraine patients often show a history of family members with migraine. This has implied that migraine might be a genetic disorder. Indeed, recent research has tied three gene defects to migraine [15]. In each case these gene changes can increase the excitability of brain cells and so, make brain more susceptible to spreading depression, and so, migraine. Much of my research is now directed to a theme recently articulated by Paul Silverman in a piece he wrote for The Scientist [4]. Dr. Silverman wrote that it is time to move past the notion of “genetic determinism.” Genetic determinism is a concept that suggests a gene defect necessarily determines whether a disease will appear. While this can be true in the extreme, it is most often not the case and certainly not the case with migraine. Instead Silverman argues that the environment of proteins made from the defective genes determines whether a disease becomes apparent. That is: Gene defects increase the likelihood a disease will appear, if the environment is right. This means those who carry a defective gene for migraine are more susceptible to get the headache from common triggers in the environment such as caffeine abstinence, skipping meals, lack of sleep, stress, etc. As noted above, however, genetic propensity to migraine can be mitigated (or reversed) by environment. Environment for proteins is the milieu they are bathed in. Environment for patients includes how they live their lives and what they are exposed to. We’ve discussed several issues about this above but let’s focus on exercise. Numerous studies in animals and humans show that a wide range of neurological diseases can be lessened by increased social, intellectual and physical activity [16-18]. Many researchers, including those in my laboratory, are studying exactly how this comes about. While that is a lengthy topic for another time, the important take-home message is that casual exercise such as walking (especially in daylight) can reduce head pain. This only needs to be casual exercise and I suspect, is therapeutic because one’s mind tends to wonder (meditate?) during the exercise and so, the patient relaxes – while generating a brain more resilient to migraine!
In fact, relaxation therapy, biofeedback [19] and perhaps yoga are activities that can lessen migraine because patients become less stressed. My suspicion is that casual physical exercise acts in a similar way. More vigorous exercise can worsen head pain, but otherwise may also be beneficial – especially if it can include a meditative aspect. For example, walking or using a treadmill can allow your mind to wonder, which can be nutritive. While research in this area is just beginning, it appears that lifestyle issues that help reduce migraine do so by altering gene expressions that affect brain cell excitability."
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http://knol.google.com/k/richard-kraig/migraine-mechanisms-and-management/DmMyZecK/h0wPsA#
Artikkelen tar for seg hva migrene er, hvorfor og behandlingsmetoder. Noe som ofte er droppet i behandlingen er fysisk aktivitet, og viktigheten av dette. Utdrag fra artikkelen omhandlende fysisk aktivitet og migrene, og viktigheten av å ikke blindt godta genetikk som forklaring alene.
"Next is exercise! This is often neglected by patients but often included by migraine specialists as an important adjunct to improving headache care. Let’s see why. Migraine patients often show a history of family members with migraine. This has implied that migraine might be a genetic disorder. Indeed, recent research has tied three gene defects to migraine [15]. In each case these gene changes can increase the excitability of brain cells and so, make brain more susceptible to spreading depression, and so, migraine. Much of my research is now directed to a theme recently articulated by Paul Silverman in a piece he wrote for The Scientist [4]. Dr. Silverman wrote that it is time to move past the notion of “genetic determinism.” Genetic determinism is a concept that suggests a gene defect necessarily determines whether a disease will appear. While this can be true in the extreme, it is most often not the case and certainly not the case with migraine. Instead Silverman argues that the environment of proteins made from the defective genes determines whether a disease becomes apparent. That is: Gene defects increase the likelihood a disease will appear, if the environment is right. This means those who carry a defective gene for migraine are more susceptible to get the headache from common triggers in the environment such as caffeine abstinence, skipping meals, lack of sleep, stress, etc. As noted above, however, genetic propensity to migraine can be mitigated (or reversed) by environment. Environment for proteins is the milieu they are bathed in. Environment for patients includes how they live their lives and what they are exposed to. We’ve discussed several issues about this above but let’s focus on exercise. Numerous studies in animals and humans show that a wide range of neurological diseases can be lessened by increased social, intellectual and physical activity [16-18]. Many researchers, including those in my laboratory, are studying exactly how this comes about. While that is a lengthy topic for another time, the important take-home message is that casual exercise such as walking (especially in daylight) can reduce head pain. This only needs to be casual exercise and I suspect, is therapeutic because one’s mind tends to wonder (meditate?) during the exercise and so, the patient relaxes – while generating a brain more resilient to migraine!
In fact, relaxation therapy, biofeedback [19] and perhaps yoga are activities that can lessen migraine because patients become less stressed. My suspicion is that casual physical exercise acts in a similar way. More vigorous exercise can worsen head pain, but otherwise may also be beneficial – especially if it can include a meditative aspect. For example, walking or using a treadmill can allow your mind to wonder, which can be nutritive. While research in this area is just beginning, it appears that lifestyle issues that help reduce migraine do so by altering gene expressions that affect brain cell excitability."
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